What histological feature is characteristic of classic Hodgkin lymphoma?

• A. Presence of lymphoblasts
• B. Presence of Reed-Sternberg cells
• C. Absence of inflammatory cells
• D. Presence of pleomorphic cells

Answer: (B)

The presence of Reed-Sternberg cells is a defining characteristic of classic Hodgkin lymphoma. These cells are large, atypical lymphoid cells that can be identified within a background of inflammatory cells in the lymph nodes. Reed-Sternberg cells are unique to Hodgkin lymphoma and serve as a key diagnostic indicator in histopathological evaluations. Their identification is crucial, as they help distinguish classic Hodgkin lymphoma from other types of lymphoid neoplasms.

In addition to their size and multi-nucleated appearance, Reed-Sternberg cells often exhibit specific immunophenotypic features, such as positivity for CD30 and CD15, further solidifying their association with Hodgkin lymphoma. Their presence in tissue samples is typically accompanied by a variety of surrounding immune cells, which are part of the characteristic inflammatory response seen in Hodgkin lymphoma, contrasting with the absence of these cells in other conditions.

Understanding the significance of Reed-Sternberg cells is fundamental in pathology, as they are pivotal in arriving at an accurate diagnosis and subsequently guiding appropriate treatment strategies for patients suffering from classic Hodgkin lymphoma.